198 Heterogeneity in cutaneous infection prevalence and frequency by timing of atopic dermatitis onset

Cutaneous infections are common in atopic dermatitis (AD) due to impaired skin barrier and immunologic dysfunction. Early- late-onset pediatric AD distinct phenotypes that vary disease persistence risk of other comorbidities. However, whether infection varies by the timing onset is unknown. Using population-based, electronic medical records data from UK, we examined a cohort children enrolled within first year life who had diagnosis before age 18. Among 154,022, 30,970, 4,788 with early- (≤ 2 years old), mid- (3-7 (8-17 old) AD, those were 20-25% less likely have molluscum (OR 0.74, 95% CI 0.68-0.80), varicella/herpes zoster (0.75, 0.70-0.79), impetigo (0.78, 0.72-0.83) herpes simplex virus (0.81, 0.69-0.96), after adjusting for age, sex, duration follow-up, atopy. They also 10% lower odds cellulitis 0.90, 0.83-0.97) warts (0.91, 0.85-0.97). Mid-onset exhibited similar slightly greater compared early-onset AD. when examining frequency infectious episodes among at least 1 episode any given (cellulitis, virus, impetigo, molluscum, tinea, zoster, or warts), did not differ was associated (adjusted IRR 0.88, 0.81-0.95) (0.92, 0.86-0.98) Taken together, our findings suggest while inversely related overall several cutaneous infections, has impact on one’s susceptibility repeated infection. Further work thus needed understand heterogeneity distinguish complicated infections.